I decided to create a series of episodes covering the different factors that can help you lower and eventually normalize your thyroid antibodies. Today, in part three of my series, I’m discussing the role of stress, which is a big factor in many people. I talk about my experiences with stress when I was dealing with Graves’ disease, when to consider adrenal testing, stress management techniques, the role of supplements, the benefits of personalized support, and more. If you would prefer to listen to this part, you can access it by Clicking Here.
In this presentation, I’m going to discuss how to lower your thyroid antibodies by addressing the stress in your life. When I say “stress,” I don’t mean just emotional stressors, but physical stressors as well. I’ll get into more detail about this shortly, but let’s go ahead and answer the following question: How can stress trigger thyroid autoimmunity?
First of all, stress can increase proinflammatory cytokines, which promote inflammation. There are other factors that can increase inflammation, but stress is one of them, essentially causing dysregulation of the immune system.
Also, stress can decrease something called secretory IgA. It lines the mucosal surfaces of the body, including the gastrointestinal tract. When someone has a lower secretory IgA, typically, they have a leaky gut, that increase in intestinal permeability.
There is something called the triad of autoimmunity, which has three components necessary for autoimmunity to develop. That includes a leaky gut. Stress can promote inflammation, causing dysregulation of the immune system, and it can also potentially increase permeability of the gut.
It’s important to understand that not all stress is equal. When it comes to emotional stressors, there is acute and chronic stress. Our body was designed to handle acute stress situations, but it wasn’t designed to handle the chronic stress that most people deal with. That is part of the problem and also part of the solution: trying to change the perception of the stressors. It’s going to be difficult, if not impossible, to completely eliminate stress from your life. I’ll talk more about addressing these stressors.
How can you tell if stress is a potential trigger? Many people have a good idea that stress is a factor. When I have an initial patient consultation, whether it’s someone who has Graves’ or Hashimoto’s, I have everyone fill out a health history.
I ask everybody to give me an idea of the stress levels and stress handling. There is a scale on the health history form, 1-10. If someone circles 10 for their stress levels, that means their stress levels are pretty high. If they put a 1 for stress handling, that means stress handling is low. A lot of people will do that. They may not put 10 for stress levels, but if they put stress on the higher side, that gives me a good idea that they are aware that stress is a factor. If they put a 1 or 2, maybe stress isn’t a factor, but many times, they’re underestimating the impact that stress has on their health or overestimating their stress handling ability.
One thing I recommend with just about everybody is to test adrenals. By testing the adrenals, you can actually see what the cortisol and DHEA levels look like. These are adrenal hormones.
Prior to my diagnosis with Graves’, I didn’t feel like stress was a factor. Even when I finally got the diagnosis of Graves’ before I did any type of adrenal testing, I thought I did a good job of handling stress. I didn’t deny that stress was a factor, but I did an adrenal saliva test and was surprised that it was as bad as it was. I had very low cortisol levels, low DHEA. I had low secretory IgA, which I tested as well.
Testing the adrenals can be helpful to see the pattern that you have. Some people have elevated cortisol levels. Not everybody has depressed cortisol levels. Some people have elevated secretory IgA.
When it comes to the different types of testing, I mentioned saliva testing; that is what I did back in 2008 when I dealt with Graves’.
There is blood testing, too. There are a few problems with blood testing. First of all, cortisol responds to stress. Some people get stressed out by getting the blood draw, so getting the blood draw can cause a false elevation of cortisol.
Another limitation of testing for cortisol in the blood is you will typically only do a single sample. Maybe you will go in the morning to get that single cortisol test done. You really want to look at the circadian pattern of cortisol. It should be at the highest level in the morning and gradually decrease throughout the day. If you’re just looking at that single cortisol level in the morning, then you’re not sure. If it’s elevated, maybe it’s elevated because you got the blood draw. Maybe if you did it at home, it wouldn’t have shown the same findings.
Not to mention you could also do it earlier. If you wake up at 6am, ideally you are supposed to collect the first saliva sample right when you wake up. The lab might not open until 8am, so you might have to wait for a couple hours to get that first sample.
There is also dried urine testing, with the DUTCH test being the most well-known dried urine test. That also looks at the circadian rhythm of cortisol. They also offer saliva testing as well. Either one will look at the circadian rhythm of cortisol and DHEA.
The DUTCH test does not look at secretory IgA. You could test secretory IgA through a comprehensive stool test. Not all saliva tests will test for secretory IgA. There are a few companies that offer that.
I do recommend, if you haven’t done so already, to consider some type of adrenal testing. Not through the blood. Typically, a saliva test or a dried urine testing.
I mentioned my Graves’ story. I underestimated the impact stress had on my health. Emotional stressors were definitely a factor, but there are also physical stressors to consider. That was the case with me as well. I was overtraining.
There are different ways you can overtrain. I have consulted with people who are running marathons and triathlons. Not to say that that’s always going to cause too much stress and lead to a chronic health condition, but if someone has a condition such as Graves’ or Hashimoto’s, they probably need to give their body a break if they are running marathons or triathlons. You don’t have to do that.
With my case, I wasn’t running marathons or triathlons. I was just working out at the gym, but I was definitely overdoing it. I was wiped out after working out. I should have known better at the time, but I didn’t. I didn’t listen to my body. I’m sharing this with you to make you understand that different stressors, even fasting-
More recently, intermittent fasting has become more and more popular. I was really restricting calories back then, really going extreme. I’m sure I wasn’t getting enough protein, and I was overtraining.
I’m not saying intermittent fasting is bad, but if someone is fasting for 20 hours a day, that’s a stressor on the body, especially if you are doing it every single day. If you are doing a 20-hour fast or a 24-hour fast once a week, many people can handle that. Not everybody. I have worked with patients who are doing 20-hour fasts every day with only a four-hour eating window. I have worked with people who are overdoing it, whether it’s at the gym or running outside in the morning.
There is also stored trauma, trauma from many years ago, even as a child, which can cause dysregulation of the nervous system and the immune system. Not to get into detail here. I do have some interviews on my podcast with Dr. Irene Cop (episode #22) and Dr. Aimie Apigian (episode #69) that you can check out.
It’s also important to mention that stress can affect the sex hormones. You need healthy adrenals in order to have healthy sex hormones. If someone has low progesterone, low estrogen, low testosterone, as we get older, yes, we do expect these to decrease, but they should be within a certain range. I really don’t like the blood test; the lab ranges I’m not crazy about.
If you look at a test like the DUTCH test, I do like their ranges. For estrogen and progesterone, the post-menopausal ranges. If you look at a blood test for progesterone in post-menopause, if it’s 0, it’s considered to be within range still. You don’t want 0 for progesterone or any sex hormone.
Let’s say you do a dried urine test, and your progesterone or estrogen or both are below the post-menopausal range. There is definitely a time and place for bioidentical hormones, but you also want to do things to optimize adrenals. Most conventional medical doctors aren’t doing that. Many aren’t doing anything. Some doctors will give bioidentical hormones, but you also want to optimize adrenals. Maybe then the person doesn’t need bioidentical hormones, or maybe they need a lower dose in that case.
How can you become a master at handling stress and therefore address this component that can affect antibodies? We can say that stress alone in many cases, just like food alone in many cases, isn’t the reason why someone has elevated antibodies. As a result, just doing things to improve stress handling might by itself not normalize antibodies.
Let’s put it this way. If someone is stressed out all the time, either emotionally or physically, it really will be difficult to lower and normalize those antibodies. This should be a piece of the puzzle, just like eating well by itself might not normalize your antibodies, but if you eat inflammatory foods, it really will be difficult to lower and normalize antibodies.
Like I said, you might want to test your adrenals if you think that everything is good. Even if you’re retired, and you think stress is low, maybe stress is low, but everybody has stress. It’s obviously different types of stress if someone is retired. They don’t have the stress associated with work. But there might be other stressors. Every now and then, someone does truly have low stress, so they are doing a good job of managing stress. A lot of people tend to underestimate the stressors and overestimate their stress handling.
When it comes to becoming a master of handling stress, a reminder: It’s the perception of the stressors. You want to try to do what you can to change the perception. Having a positive mindset alone isn’t going to be the answer, but that does play a role.
One thing I would recommend is keeping a gratitude journal daily, writing down three things at night before you go to bed and in the morning. Maybe most days, it’s the same three things. Realizing that you do have things to be grateful for because when it comes to chronic stressors, a lot of it is just thinking about the negative impact of our jobs and finances and relationships. These could be serious stressors. There are others that I didn’t mention here.
Sometimes, there is not a whole lot we can do about these stressors, at least in the short term. Writing a gratitude journal every single day, preferably twice a day, reminds us that we should really be grateful. Everybody does have some things to be grateful about, no matter how difficult life may be.
I do recommend incorporating one or more stress management techniques, whether it’s deep breathing, meditation, yoga, biofeedback, even hypnotherapy. There are a lot of different options. You want to choose at least one that you are willing to do.
If you’re not doing anything currently, or if you’re not doing anything daily- Let’s say you’re doing yoga three days a week. I would say go a step further and block out time every single day. Start with five minutes a day, or even three minutes. Let’s say five minutes per day; most people can find five minutes per day to get into the routine of stress handling.
This is similar to exercise. With many people, you need to get into a routine of exercising. If you go every now and then, a lot of people will eventually stop going. A lot of people will get into a routine and stop, too. But a lot of people will get into a routine and eventually increase the duration.
Maybe you increase the duration only a few days per week. For example, maybe you start out with five minutes every single day, doing deep breathing. Then after a few weeks, Monday, Wednesday, Friday, you spend 10 minutes doing deep breathing, and then five minutes the other days. Maybe you increase it to 15 minutes per day. If you want to do it every single day, eventually go from five minutes a day to 10 minutes every single day to 15 minutes every single day. Keep in mind you don’t have to. Obviously, the more you do, the better.
A lot of this is just by getting into the routine of stress handling. Let’s say you’re blocking out time in the morning or evening to do some deep breathing. In the middle of the day, you have a stressful event at work or an argument with a friend or family member. Hopefully, by getting into the routine, you’ll incorporate that at the time, or maybe right after. You have something happen at work. During that time, you’re stressed out. Then you take five minutes right after the incident to do some deep breathing. That can greatly help. Highly recommend this.
I need to talk about the importance of getting quality sleep each night. At least 7-8 hours a night. Sure, there might be some people who can get by with six hours or less. There are some genetics that have shown that some people might not need 7-8 hours. I’d say the majority of people, especially those who are dealing with an autoimmune thyroid condition, probably should get at least seven hours’ sleep. That doesn’t mean seven hours in bed, but seven hours asleep. If you take 15 minutes to fall asleep, you want to be in bed for seven hours and 15 minutes.
You want to set yourself up for success when it comes to sleeping, meaning you want to have a good sleep environment. Make sure the room is completely dark at night. Minimize the use of electronics before going to bed. Try not to do anything that stresses you out before going to bed, like watching the news, for example. Don’t eat too late. I recommend two hours after eating dinner before going to bed. Three hours is even better.
There are a lot of factors that can affect sleep: Blood sugar issues and adrenal problems are two of the most common ones. Adrenal problems relate to what I’m talking about here. I understand that some people listening to this might have difficulties falling and/or staying asleep. It’s something you need to work on. It may be something you have worked on, but you need some help from functional medicine practitioners. Something to consider.
Nutritional supplements and herbs. I like them, but they aren’t a replacement for blocking out time for stress management. I mentioned a gratitude journal, so that’s important. Supplements aren’t taking the place of that either. Sometimes, they can be helpful.
When I dealt with Graves’, I saw my adrenals were really low, so I took some nutritional supplements and herbs. I took licorice root for the low cortisol, which extends the life of cortisol. If someone has high blood pressure, licorice root is a contraindication, so it’s not a good fit for everyone.
Taking B vitamins is something I did. Vitamin C. There are other things, too. Adrenal glandulars, rhodiola, holy basil, eleuthero or Siberian ginseng, ashwagandha.
I love ashwagandha, but it is a member of the nightshade family. It can also support adrenals and the HPA (hypothalamic pituitary adrenal) axis, but it can also affect the HPT (hypothalamic pituitary thyroid) axis. For some people, it can increase the hyperthyroidism. Just something to be aware of.
I’ve had patients with hyperthyroidism, including Graves’, take ashwagandha. Usually, it’s part of a formulation, not by itself. Even as part of a formula, it won’t have as much ashwagandha as when you take it by itself, but still, sometimes, it can cause hyperthyroidism or increase hyperthyroidism. If that’s the case, when you stop it, it usually resolves.
Phosphatidylserine is something that can help, especially with higher cortisol levels. There are a lot of natural agents that can help with supporting adrenals. There are things that can help with anxiety, like L-theanine, for example. I do recommend working with a practitioner, not just randomly taking supplements. I also did adrenal testing, so I also didn’t randomly take the supplements. I didn’t take all the supplements I just mentioned.
I want to finish up by talking about the Vagus nerve. You have the parasympathetic system, which is the rest and digest system, and then you have the sympathetic nervous system, the fight or flight system. Most of the time, you want the parasympathetic nervous system to predominate. Certainly not all the time. A big way to accomplish this is by doing Vagus nerve exercises. Vigorous gargling is one thing you can do. Singing loud, either in the shower or in your car or somewhere else. Taking cold showers can also help. I have an article on my website about these exercises.
That’s pretty much all I wanted to cover with regard to the impact that stress has on the antibodies. Again, it’s a piece of the puzzle. Just managing your stress alone usually is not going to normalize the thyroid antibodies. It does play a significant role. Optimizing your adrenals is very important. Definitely something you want to pay close attention to.
I hope you found this information to be valuable. As usual, I look forward to catching you in the next episode.